TAK-243 preferentially certain to UBA1 more than the associated E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 decreased amounts of ubiquitylated proteins, enhanced markers of proteotoxic tension and DNA problems tension. In vivo, TAK-243 minimized leukemic load and qualified leukemic stem cells with https://bernardp530glp3.wannawiki.com/user