The ubiquitin proteasome system (UPS). particularly its deubiquitinating enzymes (DUBs). play a key role in the replication cycle of coronaviruses. The SARS-CoV-2 papain-like protease (Plpro) is known to process the viral polyproteins to form the replicase transcriptase complex and to counteract the host viral response. https://www.opheliasmuse.com/