There exists a launch of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors within the dorsal horn to lower afferent pain transmission and produce analgesia. For that reason, medications like clonidine that concentrate on alpha-two receptors can affect the transmission of pain. Relates to clonidine: oral https://tinybookmarks.com/story19720401/not-known-factual-statements-about-onolidine