There is a launch of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors within the dorsal horn to reduce afferent agony transmission and develop analgesia. Consequently, medicines like clonidine that goal alpha-two receptors can affect the transmission of soreness. For people who get dizzy when standing: https://johsocial.com/story10356749/the-2-minute-rule-for-onolidine